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Thursday, March 5, 2015

All about Protein Data Bank

Amylase

Amylase is a digestive enzyme that acts on starch in food, breaking it down into smaller carbohydrate molecules. The enzyme is made in two places. First, salivary glands in your mouth make salivary amylase, which begins the digestive process by breaking down starch when you chew your food, converting it into maltose, a smaller carbohydrate. When starchy foods like rice or potatoes begin to break down in your mouth, you might detect a slightly sweet taste as maltose is released. Cells in your pancreas make another type of amylase, called pancreatic amylase, which passes through a duct to reach your small intestine. Pancreatic amylase completes digestion of carbohydrate, producing glucose, a small molecule that is absorbed into your blood and carried throughout your body.






Primary citation 


Structure of human salivary alpha-amylase at 1.6 A resolution: implications for its role in the oral cavity.
Ramasubbu, N.,  Paloth, V.,  Luo, Y.,  Brayer, G.D.,  Levine, M.J.
Journal: (1996) Acta Crystallogr.,Sect.D 52: 435-446
PubMed: 15299664  
DOI: 10.1107/S0907444995014119   
Search Related Articles in PubMed  


Classification
Hydrolase (o Glycosyl)
Structure Weight
56031.33 
Molecule
Amylase
Polymer
1
Type : protein
Length : 496
Chains
A
EC#
3.2.1.1
Details
Human Salivary Amylase
Organism
Homo sapiens



Protease



Any enzyme that breaks down protein into its building blocks, amino acids, is called a protease, which is a general term. Your digestive tract produces a number of these enzymes, but the three main proteases are pepsin, trypsin and chymotrypsin. Special cells in your stomach produce an inactive enzyme, pepsinogen, which changes into pepsin when it contacts the acid environment in your stomach. Pepsin breaks certain chemical bonds in proteins, producing smaller molecules called peptides and beginning protein digestion. Your pancreas makes trypsin and chymotrypsin, enzymes that are released into your small intestine through the pancreatic duct. When partially digested food moves from your stomach into your intestine, trypsin and chymotrypsin complete protein digestion, producing simple amino acids that are absorbed into your circulation.



Structure of Protease 
Primary Citation


Journal: (2004) Acta Crystallogr.,Sect.D 60: 256-259
PubMed: 14747701
DOI: 10.1107/S090744490302599X
Search Related Articles in PubMed
PubMed Abstract:
V8 protease, an extracellular protease of Staphylococcus aureus, is related to the pancreatic serine proteases. The enzyme cleaves peptide bonds exclusively on the carbonyl side of aspartate and glutamate residues. Unlike the pancreatic serine proteases, V8 protease possesses no disulfide..       [ Read More & Search PubMed Abstracts ]

Classification
Protease
Structure Weight
29715.10
Molecule
Serine Protease
Polymer
1
Type : protein
Length : 274
Chains
A
EC#
3.4.21.19
Details
Staphylococcus aureus subsp. aureus Mu50
Gene Names
sspA SAV1048

SOURCE FROM rcsb.org



Lipase

Lipase is an enzyme that breaks down dietary fats into smaller molecules called fatty acids and glycerol. A small amount of lipase, called gastric lipase, is made by cells in your stomach. This enzyme specifically digests butter fat in your food. The main source of lipase in your digestive tract is your pancreas, which makes pancreatic lipase that acts in your small intestine. First, bile made in your liver and released into your intestine converts dietary fat into small fatty globules. Pancreatic lipase, also called steapsin, acts on these fat globules, converting them into fatty acids and glycerol, which are small, energy-dense molecules used by all your cells. Fatty acids and glycerol travel in blood and your lymph vessels to reach all parts of your body.

Primary Citation

Journal: (2012) Plos One 7: e52890-e52890
PubMed: 23300806  
PubMedCentral: PMC3530535  
DOI: 10.1371/journal.pone.0052890   
Search Related Articles in PubMed  
PubMed Abstract:
Bacterial lipases from family I.1 and I.2 catalyze the hydrolysis of triacylglycerol between 25-45°C and are used extensively as biocatalysts. The lipase from Proteus mirabilis belongs to the Proteus/psychrophilic subfamily of lipase family I.1 and is a promising catalyst for... [ Read More & Search PubMed Abstracts ]





Classification
Hydrolase
Structure Weight
34560.21
Molecule
Putative Lipase
Polymer
1
Type : protein
Length : 307
Chains
A
EC#
3.1.1.3
Gene Names
PMI0999
Organism
Proteus mirabilis



SOURCE FROM rcsb.org

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